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The peptides suppress ASIC channel activity both in central neurons and in peripheral nociceptors.

In addition to their potential for yielding novel painkillers with superior side effect profiles, the mambalgins are already revealing unappreciated functions of ASIC channels and new therapeutic targets.

Eric Lingueglia and his colleagues at the Institut de Pharmacologie Moléculaire et Cellulaire in Valbonne, France, including Sylvia Diochot—an engineer specializing in animal venoms and toxins—and Anne Baron, reported the findings in the October 3 Nature.

The new study shows the mambalgins inhibit the activity of multiple acid-sensing ion channels (ASICs), which are major players in pain pathways responding to tissue acidification—a common feature of many pain-generating conditions including acute heat pain and inflammation.